Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome
نویسندگان
چکیده
منابع مشابه
Necroptosis as a potential therapeutic target in multiple organ dysfunction syndrome
PURPOSE To investigate how necroptosisis, i.e. programmed necrosis, is involved in MODS, and to examine whether Nec-1, a specific necroptosis inhibitor, ameliorates multiorgan injury in MODS. EXPERIMENTAL DESIGN A model of MODS was established in six-week old SD rats using fracture trauma followed by hemorrhage. Control animals received sham surgery. Cell death form and necrosome formation we...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.18252